Using voltage divider, the Vout should be 2.5 V using an ideal voltmeter. In reality, a voltmeter will never be able to have infinite resistance and so could affect your readings if dealing with resistances that are close to the internal resistance of your measuring device. In the pic on the left, we used 10M ohm resistors. Since the DMM's internal resistance is 10M ohm as well, it ends up being in parallel with the 10M ohm resistor it's measuring, lowering the equivalent resistance of the two to 5M ohm. This changes the circuit causing only 1.666 V to drop across the resistor we were measuring. In the right photo, we used much smaller resistors, only 100k ohm. Since they were so much smaller compared to the internal resistance of the DMM, it was able to act as an ideal voltmeter and not distort the readings as happened previously.